Diego de Siloé was one of the principal exponents of Renaissance architecture in Spain. he executed the Escalada Dorada in the north transept of Burgos Cathedral (1520-22). In Granada, he executed the choir of San Jerónimo (1528-43), and provided new plans for Granada Cathedral (1528), considered the finest of all Plateresque buildings. In 1526, he had designed the east end of Málaga Cathedral. In 1535, he designed a splendid new cupola for the main sacristy in Seville Cathedral, begun by Diego de Riaño.
His buildings reveal Diego de Siloé as one of the most original architects of the Spanish Renaissance.