Panfilo Nuvolone painted many frescoes and altarpieces, in a style still linked to late Mannerism, and a number of more original still-lifes. His son Carlo Francesco Nuvolone, who responded to early 17th-century Milanese art, was a more powerful artist. He became the leading painter in Lombardy in the mid-17th century, producing frescoes, altarpieces, devotional works and portraits. Carlo's younger brother Giuseppe Nuvolone assisted him. Giuseppe's art is of lower quality, yet richer in colour, and his many religious works spread the Baroque style throughout Lombardy. His son Carlo Nuvolone (active 1650–1700), a mediocre quadratura specialist, probably worked in Giuseppe's studio and was active mainly around Cremona.