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Isabella d'Este kept her precious art collection in two locked treasure chambers close to her studiolo, each of which she called 'grotta.' She moved all her furniture and her works of art from her earlier rooms, including the wooden intarsias of musical instruments and perspective vistas by the Mola brothers.
In the Renaissance period, intarsia was widely used for decorating both churches and the palaces of the nobility. It often presents musical instruments. The brothers Antonio and Paolo Mola were famous for their intarsia works, they were active in Mantua and Venice.
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