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Ercole II d'Este (1508-1559) was Duke of Ferrara, Modena and Reggio from 1534 to 1559. He was the eldest son of Alfonso I d'Este and Lucrezia Borgia. Through his mother, Ercole was a grandson of Pope Alexander VI, nephew of Cesare Borgia, and cousin of Saint Francis Borgia. Through his father, he was nephew of both Isabella d'Este, "the First Lady of the Renaissance", and Cardinal Ippolito d'Este.
Inscription around circumference: HERCVLES ESTENSIS II FERR[ariae] DVX IIII; around right circumference: POMPEIVS.
The reverse of the medal shows the allegorical figure of Patience.
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