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In 1474 Laurana was back in Naples; it is not known how long he stayed. The Virgin and Child in Santa Maria Mater Domini, Naples, is attributed to him and may date from this period.
The design of the façade of Santa Maria Materdomini is attributed to the architect Giovanni Francesco di Palma. It has a simple entrance portal surmounted by a niche in which was placed the statue of the Virgin and Child by Francesco Laurana. The statue is currently placed on the high altar.
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